| 1 | 2021-04-10 14:00:00Sat 10 Apr 2021 | Hampton Rovers v Old Ivanhoe | 90 - 62 | Boss James Reserve |
| 2 | 2021-04-17 14:00:00Sat 17 Apr 2021 | UHSVU v Hampton Rovers | 31 - 196 | Brens Oval |
| 3 | 2021-04-24 14:00:00Sat 24 Apr 2021 | Hampton Rovers v Monash Blues | 14:00:002:00 pm | Boss James Reserve |
| 4 | 2021-05-01 14:00:00Sat 1 May 2021 | Ormond v Hampton Rovers | 14:00:002:00 pm | EE Gunn Reserve |
| 5 | 2021-05-08 14:00:00Sat 8 May 2021 | Hampton Rovers v Preston Bullants | 14:00:002:00 pm | Boss James Reserve |
| 6 | 2021-05-15 14:00:00Sat 15 May 2021 | Hampton Rovers v Old Mentonians | 14:00:002:00 pm | Boss James Reserve |
| 7 | 2021-05-22 14:00:00Sat 22 May 2021 | Mazenod v Hampton Rovers | 14:00:002:00 pm | Central Reserve |
| 8 | 2021-05-29 14:00:00Sat 29 May 2021 | Hampton Rovers v Marcellin | 14:00:002:00 pm | Boss James Reserve |
| 9 | 2021-06-05 14:00:00Sat 5 Jun 2021 | Old Geelong v Hampton Rovers | 14:00:002:00 pm | Como Park |
| 10 | 2021-06-19 14:00:00Sat 19 Jun 2021 | Hampton Rovers v Mazenod | 14:00:002:00 pm | Boss James Reserve |
| 11 | 2021-06-26 14:00:00Sat 26 Jun 2021 | Monash Blues v Hampton Rovers | 14:00:002:00 pm | Frearson Oval |
| 12 | 2021-07-03 14:00:00Sat 3 Jul 2021 | Old Ivanhoe v Hampton Rovers | 14:00:002:00 pm | Chelsworth Park |
| 13 | 2021-07-24 14:00:00Sat 24 Jul 2021 | Hampton Rovers v Ormond | 14:00:002:00 pm | Boss James Reserve |
| 14 | 2021-07-31 14:00:00Sat 31 Jul 2021 | Old Mentonians v Hampton Rovers | 14:00:002:00 pm | Keysborough Playing Fields |
| 15 | 2021-08-07 14:00:00Sat 7 Aug 2021 | Hampton Rovers v Old Geelong | 14:00:002:00 pm | Boss James Reserve |
| 16 | 2021-08-14 14:00:00Sat 14 Aug 2021 | Marcellin v Hampton Rovers | 14:00:002:00 pm | Marcellin College |
| 17 | 2021-08-21 14:00:00Sat 21 Aug 2021 | Preston Bullants v Hampton Rovers | 14:00:002:00 pm | Ruthern Reserve |
| 18 | 2021-08-28 14:00:00Sat 28 Aug 2021 | Hampton Rovers v UHSVU | 14:00:002:00 pm | Boss James Reserve |
Hampton Rovers
Monash Blues
Marcellin
Ormond
